Makinti Napanangka was born at Lupul rockhole, south of Kintore.
Her first contact with Europeans was with men travelling on camels near Lupul. She walked with her husband, Nyukuti Tjupurrula (Nosepeg's brother), to Haasts Bluff in the early 1940s. She gave birth to her first child in the Lake MacDonald area and later had children in Haasts Bluff, Papunya and Alice Springs.
Makinti began to paint in acrylic on canvas in mid-1994 for the Minyma Tjukurrpa (Kintore/Haasts Bluff Project). Her work was first exhibited in a group show at Tandanya, Adelaide, in mid-1995. She also made batik at the Kintore batik workshop in 1994.
The artist began to paint for Papunya Tula when the newly appointed field officer, Wayne Eager, began distributing canvas in 1996 to senior Pintupi women at Kintore, where Makinti lives and works.
Makinti is a cousin of Tatali Nangala (c.1925-99), with whom she often painted. Makinti held a solo exhibition of her work at Utopia Art Sydney in 2000. Makinti was selected to participate in the Clemenger Contemporary Art Award of 2003.