Creating pieces of brain tissue using stem cells
BY Mirella Dottori
THEME LEADER Peter Lee
SUPPORTED BY University of Melbourne, as part of the NGV Triennial – exploring the emerging intersections of art, design, science and society.
Associate Professor Mirella Dottori’s research lies within the field of human pluripotent stem cell biology, which is one of the most rapidly advancing areas of medical research. Pluripotent cells can now be generated from human biopsy tissue and this technology allows the possibility of generating patient-specific stem cells for the development of cell replacement as well as genetically appropriate human cellular models in vitro. For Triennial Voices, Associate Professor Dottori shares images of stem cell-derived brain organoids, which were generated by her PhD student, Cristiana Mattei, showing ‘hair-like’ cilia, which are found in the developing ear region of the brain. These studies are conducted in collaboration with Associate Professor Bryony Nayagam (Bionics Institute, University of Melbourne) and Dr Rebecca Lim (University of Newcastle).
- Podcast: Timothy Moore interviews Mirella Dottori
Inner ear organoids generated from human stem cells. Organoids consist of clusters of neurons as detected by nuclear (shown in blue) and cytoplasmic (shown in red) stainings.
Associate Professor Mirella Dottori is an ARC Future Fellow and Group Leader of the Stem Cell Laboratory at the Centre for Neural Engineering, University of Melbourne.
Timothy Moore is director of architecture practice Sibling.
Mirella Dottori Principal Research Fellow, Group Leader
Ana Antonic, Research fellow
Giovanna D’Abaco , Research Fellow and Lab Manager
Rachael Chatterton, Research Assistant
Pegah Jamshidi, Research Assistant
Tejal Kulkarni, Research Assistant
Abdullah Alshawaf, PhD student
Cristiana Mattei, PhD student
Serena Viventi, PhD student
Michal Mor Easton, PhD student
Kwaku Dad Abu-Bonsrah, PhD student
Ting Ting Lee, PhD student
Emma Hudson, Masters student