Lived: 24 October 1503 – 1 May 1539
Wife and cousin of Charles I.
Although it was a politically arranged marriage, Isabel and Charles were instantly attracted to one another. Isabel was Charles’s greatest stalwart, ruling Spain competently during his absences. Sadly she died after giving birth to their sixth child. Charles I was so devastated that he never re-married and he wore black for the rest of his life signifying his perpetual mourning.